更新日:2008年12月26日
- 論文
- 委員会承認の治療研究
- JCOG0404
- S Kitano, M Inomata, A Sato, et al: Randomized controlled trial to evaluate laparoscopic surgery for colorectal cancer: Japan Clinical Oncology Group Study JCOG0404. Jpn J Clin Oncol 35: 475-477, 2005
- グループ代表者管理の治療研究
なし
- 附随研究等
- M Higashiyama, M Kameyama, et al.: Intraoperative lavage cytologic analysis of surgical margins as a predictor of local recurrence in pulmonary metastasectomy. Archive Surgery. 137: 469-474, 2002.
- K Komatsu, M Kameyama, et al.: Expression of S100A6 and S100A4 in matched samples of human colorectal mucosa, primary colorectal adenocarcinoma and liver metastases. Oncology. 63: 192-200, 2002.
- T Ito, H Nakanishi, T Kato, et al.: Quantitative detection of CEA expressing free tumor cells in the peripheral blood of colorectal cancer patients during surgery with real-time RT-PCR on a Light Cycler. Cancer Letters. 183: 195-203, 2002.
- T Kato, Y Ohashi, H Nakazato, et al.: Efficacy of oral UFT as adjuvant chemotherapy to curative resection of colorectal cancer: multicenter prospective randomized trial. Langenbeck's Arch Surg. 386: 575-581, 2002.
- M Ikenaga, N Tomita, I Nishisho, et al.: Use of microsatellite analysis in young patients with colorectal cancer to identify those with hereditary nonpolyposis colorectal cancer. Journal of Surgical Oncology. 79: 157-165, 2002.
- S Kohnoe, K Endo, T Okamura, et al.: Protracted hepatic arterial infusion with low-dode cisplatin plus 5- fluorouracil for unresectable liver metastases from colorectal cancer. Surgery. 131: S128-34, 2002.
- Y Namiki, K Muro, Y Shimada, et al.: Prognostic factors for patients with metastatic colorectal cancer receiving protracted venous infusion of 5-FU. Am J Clin Oncol. 25: 182-186, 2002.
- Y Matsumura, K Haruyama, Y Shimada, et al.: Effect of a 3-hour interval between methotrexate and 5-fluorouracil in the treatment of metastatic colorectal cancer. Jpn J Clin Oncol. 32: 9-13, 2002.
- A Ohtsu, N Boku, Y Shimada, et al.; Japan Clinical Oncology Group: A Phase II study of irinotecan in combination with 120-h infusion of 5-fluorouracil in patients with metastatic colorectal carcinoma: Japan Clinical Oncology Group Study (JCOG9703). Jpn J Clin Oncol. 33: 28-32, 2002.
- T Akasu, T Yokoyama, Y Moriya, et al.: Peroral sustained-release indomethacin treatment for rectal adenomas in familial adenomatous polyposis: a pilot study. Hepato-Gastroenterology. 49: 1259-1261, 2002.
- M Kubo, M Sakamoto, Y Moriya, et al.: Less aggressive features of colorectal cancer with liver metastases showing macroscopic intrabiliary extension. Pathology International. 52: 514-518, 2002.
- S Aoki, Y Nakanishi, Y Moriya, et al.: Prognostic significance of laminin-5γ2 chain expression in colorectal carcinoma. Dis Col Rec. 45: 1520-1527, 2002.
- WH Steup, Y Moriya, CJ van de Velde: Patterns of lymphatic spread in rectal cancer. A topographical analysis on lymph node metastases. Eur J Cancer. 38: 911-918, 2002.
- N Saito, K Koda, N Takiguchi, et al.: Curative surgery for local pelvic recurrence of rectal cancer. Dig Surg.20: 192-200, 2002
- 加藤孝一郎、亀山雅男、他:大腸癌に対する全身化学療法の現況-第16回大腸疾患外科療法研究会アンケート調査結果-.癌と化学療法. 29:895-903, 2002.
- 固武健二郎、他:Carmofur(HCFU)を用いた大腸癌の術前化学療法─無作為化比較対照試験による多施設共同研究─.癌と化学療法. 29(11):1917-1924, 2002.
- 万井真理子、西庄 勇、三嶋秀行、他:高齢者大腸癌症例の臨床病理学的検討. 日本消化器外科学会雑誌. 35(6):590-597, 2002.
- Y Miyakura, K Kotake, et al.: Methylation profile of the MLH1 promoter region and their relationship to colorectal carcinogenesis. Genes Chromosomes Cancer. 36: 17-25, 2003.
- S Yamamoto, T Akasu, Y Moriya, et al.: Long-term Prognostic Value of Conventional Peritonal Cytology after Curative Resection for Colorectal Carcinoma. Jpn J Clin Oncol. 33: 33-37, 2003.
- S Aoki, T Shimamura, T Shibata, et al.: Prognostic significance of dysadherin expression in advanced colorectal carcinoma. Br J Cancer. 88: 726-732, 2003.
- Y Moriya, T Akasu, S Fujita, et al.: Aggressive surgical treatment for patients with T4 rectal cancer. Colorectal Dis. 5: 427-431, 2003.
- S Fujita, T Shimoda, K Yoshimura, et al.: Prospective evaluation of prognostic factors in patients with colorectal cancer undergoing curative resection. J Surg Onclol. 84: 127-131, 2003.
- S Fujita, S Yamamoto, Y Moriya, et al.: Lateral pelvic lymph node dissection for advanced lower rectal cancer. Br J Surg. 90: 1580-1585, 2003.
- K Kotake, S Honjo, K Sugihara, et al.: Changes in colorectal cancer over a 20-year period: an extended report from the Multi-institutional Registry of the Large Bowel Cancer, Japan. Dis Colon Rectum. 46(10): S32-S43, 2003.
- K Koda, M Mitasaki, H Sarashina, et al.: A randomized controlled trial of postoperative adjuvant immunochemtherapy for colorectal cancer with oral medicines. Int J Oncology.23: 165-172, 2003.
- T Kato, K Yasui, T Hirai, et al.: Therapeutic Results for hepatic metastasis of colorectal cancer with special reference to effectiveness of hepatectomy: analysis of prognostic factors for 763 cases recorded at 18 institutions. Dis Colon Rectum. 46 Suppl:S22-S31, 2003.
- Y Adachi, K Sato, K Kakisako, et al.: Quality of life after laparoscopic or open colonic resection for cancer. Hepato-Gastroenterology. 50(53): 1348-1351, 2003.
- H Hasegawa, Y Kabeshima, M Watanabe, et al.: Randomised Controlled Trial of Laparoscopic Versus Open Colectomy for Advanced Colorectal Cancer. Surgical Endoscopy. 17(4):636-640, 2003.
- M Watanabe, H Hasegawa, S Yamamoto, et al.: Laparoscopic surgery for stage 1 colorectal cancer: long-term outcome. Surgical Endoscopy. 17(8):1274-1277, 2003.
- S Yamamoto, M Watanabe, H Hasegawa, et al.: Short-Term Surgical Outcomes of Laparoscopic Colonic Surgery in Octogenarians: A Matched Case-Control Study. Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 13:95-100,2003.
- 河原正樹、加藤知行、森 武生、他:本邦における大腸癌同時性肝転移に対する治療の現況(第2報):全国アンケート追跡調査結果. 日本大腸肛門病学会雑誌. 56:55-61, 2003.
- 平井 孝、加藤知行、金光幸秀:炎症性腸疾患と大腸癌:第55回大腸癌研究会アンケート結果. 胃と腸. 37:887-893, 2003.
- 藤田 伸、森谷冝皓、赤須孝之、他:直腸癌側方郭清に意義はあるか-意義ありとする立場から. Frontiers in Gastroenterology. 9:120-127, 2004.
- K Koda, N Saito, K Oda, et al.: Evaluation of lateral lymph node dissection with preoperative chemo-radiotherapy for the treatment of advanced middle to lower rectal cancers. Int J Colorectal Dis. 19: 188-194, 2004.
- N Saito, M Ono, M Sugito, et al.: Early results of intersphincteric resection for patients with very low rectal cancer an active approach to avoid a permanent colostomy. Dis Colon Rectum 47: 459-466, 2004.
- K Shirouzu, Y Ogata, Y Araki: Oncologic and functional results of total mesorectal excisionand autonomic nerve-preserving operation for advanced lower rectal cancer. Dis Colon Rectum. 47: 1442-1447, 2004.
- S Kitano, M Inomata, et al.: Randomized controlled trial to Evaluate Laparoscopic surgery for colorectal cancer: Japan clinical oncology group study JCOG 0404. Jpn J Clin Oncol. (In Press), 2005.
- S Yamamoto, S Fujita, T Akasu, et al.: A comparison of the complication rates betweenlaparoscopic colectomy and laparoscopic low anterior resection. Surgical Endoscopy. 18: 1447-1451, 2004.
- 関本貢嗣、門田守人、他:大腸癌に対する開腹術と腹腔鏡下手術の比較 RCTの結果と欧米での評価. 外科治療. 92(1):15-21, 2005.
- 平井孝、加藤知行、金光幸秀:大腸癌肝転移に関する研究-大腸癌の肝転移に対する外科治療. 大腸疾患NOW. 89-104, 2004.
- M Inokuchi, H Uetake, Y Shirota, et al.: Gene expression of 5-fluorouracilmetabolic enzymes in primary colorectal cancer and corresponding liver metastasis. Cancer Chemother Pharmacol 53: 391-396, 2004.
- A Goto A, Y Yamada, A Hosokawa, et al.: Phase I/II study of irinotecan, 5-fluorouracil, and l-leucovorin combination therapy (modified Saltz regimen) in patients with metastatic colorectal cancer. Int J Clin Oncol. 9: 364-368, 2004.
- A Hosokawa, Y Yamada, Y Shimada, et al.:.Prognostic significance of thymidylate synthase in patients with metastatic colorectal cancer who receive protracted venous infusions of 5-fluorouracil. Int J Clin Oncol. 9: 388-392, 2004.
- Y Moriya, T Akasu, S Fujita, et al.: Total pelvic exenteration with distal sacrectomy for fixed recurrent rectal cancer in the pelvis. Dis Colon Rectum. 47: 2047-2053, discussion 2053-2054, 2004.
- Y Kondo: A Pilot Study of Capecitabine in advanced or recurrent colorectal cancer. Jpn J Clin Oncol. 34(4):195-201, 2004.
- H Ueno, H Mochizuki, et al.: Predictors of extrahepatic recurrence after resection of colorectal liver metastases. Brit J Surg. 91:327-333, 2004.
- H Ueno, H Mochizuki, et al.: Risk factors for an adverse outcome in early invasive colorectal carcinoma. Gastroenterology. 127:385-394, 2004.
- H Ueno, H Mochizuki, et al.: Preoperative parameters expanding the indication of sphincter preserving surgery in patients with advanced low rectal cancer. Ann Surg. 239:34-42, 2004.
- H Ueno, H Mochizuki, et al.: A new prognostic staging system for rectal cancer. Ann Surg. 240:832-839, 2004.
- E Shinto, H Mochizuki, et al.: The subserosal elastic lamina: an anatomic landmark for stratifying pT3 colorectal cancer. Dis Colon Rectum. 47:467-473, 2004.
- K Koinuma, K Shitoh, F Konishi, et al.: Mutations of BRAF are associated with extensive hMLH1 promoter methylation in sporadic colorectal carcinomas. Int.J.Cancer. 108:237-242, 2004.
- F Konishi: Colorectal cancer in Japan. Textbook of tropical surgery. 494-496, 2004.
- T Iwama, K Tamura, K Sugihara, et al.: A clinical overview of familial adenomatous polyposis derived from the database of the Polyposis Registry of Japan. Int J Clin Oncol. 9:308-316, 2004.
- Y Kanemitsu, T Kato, T Hirai, et al.: Preoperative probability model for predicting overall survival after resection of pulmonary metastases from colorectal cancer. Br J Surg. 91:112-120, 2004.
- O Takaya, H Yamamoto, m Fukunaga, et al.: Application of RT-PCR to clinical diagnosis of micrometastasis of colorectal cancer: A translational research study. Int J Oncol. 25:597-604, 2004.
- N Tomita, M Ooto: Molecular genetic diagnosis for familial tumors. Int J Clin Oncol. 9:246-256, 2004.
- N Tomita, M Fukunaga, S Okamura, et al.: The novel germline mutation of the hMLH1 gene in a case of suspected hereditary non-polyposis colorectal cancer (HNPCC) in a p atient with no family history of cancer. Jpn J Clin Oncol. 34:556-560, 2004.
- S Yamamoto, S Fujita, Y Moriya, et al.: Safety of laparoscopic intracorporeal rectal transection with double-stapling technique anastomosis. Surg Laparosc Endosc Percutan. Tech 15:1-5, 2005.
- S Yamamoto, S Fujita, Y Moriya, et al.: Postsurgical surveillance for recurrence of UICC stage I colorectal carcinoma: Is follow-up by CEA justified? Hepato- gastroenterology. 52:444-449, 2005.
- Y Moriya, T Akasu, S Fujita, et al.: Total pelvic exeteration with distal sacrectomy for fixed recurrent rectal cancer. Surg Oncol Clin N Am. 14:225-238, 2005.
- H Matsushita, Y Matsumaru, Y Moriya, et al.: A new method for isolating colonocytes from naturally evacuated feces and its clinical application to colorectal cancer diagnosis. Gastroenterology. 129:1918-1927, 2005.
- K Koda, N Saito, K Seike, et al.: Denervation of the neorectum as a potential cause of defecatory disorder following low anterior resection for rectal cancer. Dis Colon & Rectum.48(2):210-217, 2005.
- S Hasegawa, K Seike, N Takiguchi, et al.: Thymidine phosphorylase expression and efficacy of adjuvant doxifluridine in advanced colorectal cancer patients. Oncol Rep. (4):621-626, 2005.
- H Tanami, H Tsuda, K Sugihara, et al.: Involvement of cyclin D3 in liver metastasis of colorectal cancer, revealed by genome-wide copy-number analysis Laboratory Investigation. 85:1118-1129, 2005.
- JH Yoo, H Hasegawa, Y Ishii, et al.: Long-term outcomeof per anum intersphincteric rectal dissection with direct coloanal anastomosis for lower rectal cancer. Colorectal Dis. 7(5):434-440, 2005.
- Y Ishii, H Hasegawa, H Nishibori, et al.: Impact of visceral obesity onsurgical outcome after laparoscopic surgery for rectal cancer. Br J Surg 2005;92(10):1261-1262, 2005.
- K Yorozuya, T Kubota, H Hasegawa, et al.:TSU-68(SU6668) inhibits local tumor growth and liver metastasis of human colon cancer xenografts via anti-angiogenesis. Oncol Rep. 14(3):677-682, 2005.
- S Yamagishi, H Shimada, S Fujii, et al.: Expression of dihydropyrimidine dehydrogenase, tymidylate synthase, p53 and p21 in metastatic liver tumor from colorectal cancer after 5-fluorouracil-based chemotherapy. Anticancer Research. 25:1237-1242, 2005.
- T Matsumoto, M Ohue, M Sekimoto, et al.: Feasibility of autonomic nerve-preserving surgery for advanced rectal cancer based on analysis of micrometastases. Bri J Surg. (11):1444-1448, 2005.
- BM Kim, H Yamamoto, M Ohue, et al.: Methylation and expression of p16INK4 tumor suppressor gene in primary colorectal cancer tissues. Int J Oncol. (5):1217-1226, 2005.
- H Fukunaga, M Sekimoto, M Ohue, et al.: Fusion image of positron emission tomography and computed tomography for the diagnosis of local recurrence of rectal cancer. Ann Surg Oncol. 12(7):561-569, 2005.
- M Ikeda, M Sekimoto, M Ohue, et al.: High incidence of thrombosis of the portal venous system after laparoscopic splenectomy. Ann Surg. 241(2):208-216, 2005.
- H Mishima: Sequential treatment with irinotecan and doxifluridine: Optimal dosing schedule in murine models and in a phase I study for metastatic colorectal cancer. Chemotherapy. 51:32-39, 2005.
- 加藤知行、他:直腸癌に対する側方郭清は必要か.日本外科学会雑誌. 67:529-533, 2005.
- T Akasu, G Iinuma, T Fujita, et al.: Thin-section MRI with a phased-array coil for preoperative evaluation of pelvic anatomy and tumor extent in patients with rectal cancer. Am J Roentgenol. 184:531-538, 2005.
- 藤田伸、山本聖一郎、赤須孝之、他:外科治療:側方郭清予防的側方郭清と治療的側方郭清.消化器外科.28(5):799-805, 2005.
- 池 秀之、齋藤修治、藤井正一、他:下部直腸癌に対する神経温存D3郭清術.手術.59(5):655-659, 2005.
- Y Moriya: Treatment strategy for locally recurrent rectal cancer. Jpn J Clin Oncol. 36:127-131, 2006.
- T Akasu, Y Moriya, Y Ohashi, et al.: Adjuvant chemotherapy with Uracil-Tegafur for pathological Stage Ⅲ rectal cancer after mesorectal excision with selective lateral pelvic lymphadenectomy: a multicenter randomized controlled trial. Jpn J Clin Oncol. 36:237-244, 2006.
- S Yamamoto, S Fujita, T Akasu, et al.: Reduction of prolonged postoperative hospital stay after laparoscopic surgery for colorectal carcinoma. Surg Endosc. 20:1467-472, 2006.
- S Fujita, H Baba, S Yamamoto, et al.: Allelic status of chromosomes 17, 18q, 22p, 3p and their clinical usefulness in colorectal cancer. Anticancer Research. 26:2833-2840, 2006.
- Y Moriya: Function-preserving surgery for rectal cancer. Int J Clin Oncol. 11:339-343, 2006.
- N Saito, Y Moriya, K Shirouzu, et al.: Intersphincteric resection in patients with very low rectal cancer. - A review of the Japanese experience- , Dis Colon & Rectum. 49(Suppl 1):S13-22, 2006.
- S Yamamoto, K Yoshimura, S Ri, et al.: The risk of multiple primary malignancies with colorectal carchinoma. Dis Colon & Rectum. 49(Suppl 1):S30-36, 2006.
- Kitano S, Kitajima M, Konishi F, et al.: A multicenter study on laparoscopic surgery for colorectal cancer in Japan. Surg Endosc. 20(9):1348-1352, 2006.
- 大植雅之、能浦真吾、佐々木洋、他:直腸癌側方リンパ節郭清の現状と今後:外科治療.95:651-658, 2006.
- 齋藤典男、鈴木孝憲、杉藤正典、他:下部直腸癌における最近の機能温存手術について.癌の臨床.52(5):403-410, 2006.
- 白水和雄、緒方 裕、赤木由人、他:下部直腸・肛門管癌に対する究極の肛門救済手術―新たなる発想と新展開―.癌の臨床.52:411-416, 2006.
- T Akasu, S Fujita, Y Moriya, et al.: Abdominal sacral resection for posterior pelvic recurrence of recatal carcinoma: analyses of prognostic factors and recurrence patterns. Ann Surg Oncol. 14:74-83, 2007.
- K Uehara, S Fujita, Y Moriya, et al.: Clinicopathological significance of fibrous tissue around the fixed recurrent rectal cancer in the pelvis. Br J Surg. 94:1530-1535, 2007.
- K Uehara, Y Moriya, et al.: Clinicopathological significance of microscopic abscess formation at the invasive margin of advanced low rectal cancer. Br J Surg.94:239-243, 2007.
- M Uehara, S Fujita, Y Moriya, et al.: Isolated right external iliac lymph node recurrence from a primary cecum carcinoma: Report of a case. Jpn J Clin Oncol. 37:230-232, 2007.
- T Nakajima , Y Moriya , et al.: Minute depressed-type submucosal invasive cancer; 5mm in diameter with intermediate lymph-node metastasis. Report of a Case. Dis Colon Rectum. 50:677-681, 2007.
- K Uehara, S Fujita, Y Moriya, et al.: Impact of Upward Lymph Node Dissection on Survival Rates in Advanced Lower Rectal Carcinoma. Dig Surg. 24:375-381,2007
- S Fujita, Y Moriya, et al.: Randomized, Multicenter Trial of Antibiotic Prophylaxis in Elective Colorectal Surgery. Archives of Surgery. 142:657-661, 2007.
- S Fujita, Y Moriya, et al.: Quantification of CD10 mRNA in colorectal cancer and relationship between mRNA expression and liver metastasis. Anticancer Res. 27:3307-3311, 2007.
- T Terauchi, Y Moriya, et al.: A case of colon cancer detected by carbon-11 choline positron emission tomography/ computed tomography: An initial report. Jpn J Clin Oncol.37:797-800, 2007.
- S Fujita, Y Moriya, et al.: Cancer invasion to Auerbach’s plexus is an important prognostic factor in patients with pT3-pT4 colorectal cancer. Dis Colon Rectum. 50:1860-1866, 2007.
- T Akasu, S Fujita, Y Moriya, et al.: Incidence and patterns of recurrence after intersphincteric resection for very low rectal adenocarcinoma. J Am Coll Surg. 205:642-7, 2007.
- S Kitano, N Shiraishi, et al.: A multicenter study on oncologic outcome of laparoscopic gastrectomy for early cancer in Japan.Ann Surg. 245:68-72, 2007.
- A Sasaki, S Kitano, et al.: Prognostic value of preoperative peripheral blood monocyte count in patients with colorectal liver metastasis after liver resection.J Gastrointest Surg 11: 596-602, 2007.
- K Yasuda, S Kitano, et al.: Risk factors for occult lymph node metastasis of colorectal cancer invading the submucosa and indications for endoscopic mucosal resection. Dis Colon Rectum. 50:1370-1376, 2007.
- M Hara, T Kato, et al.: Isolated tumor cell in lateral lymph node has no influences on the prognosis of rectal cancer patients. Int J Colorectal Dis. 22:911-917, 2007.
- Y Shimizu, T Kato, et al.: Treatment strategy for synchronous metastases of colorectal cancer: is hepatic resection after an observation interval appropriate? Langenbecks Arch Surg. 392:535-538, 2007.
- J Sakamoto, T Kato, et al.: An individual patient data meta-analysis of adjuvant therapy with uracil-tegafur (UFT) in patients with curatively resected rectal cancer. Br J Cancer. 96:1170-1177, 2007.
- M Hara, T Kato, et al.: Comparative analysis of intraperitoneal minimal free cancer cells between colorectal and gastric cancer patients using quantitative RT-PCR: possible reason for rare peritoneal recurrence in colorectal cancer. Clin Exp Metastasis. 24:179-189, 2007
- 総説・解説
- 島田安博:大腸癌化学療法の現状. 大腸疾患NOW. 117-127, 2005.
- 山本聖一郎、藤田伸、赤須孝之、他:直腸癌に対する自律神経温存手術. 手術. 58: 1819-1825, 2004.
- 榎本雅之、小林宏寿、朴成進、他:神経温存直腸癌手術. 手術. 58: 53-57, 2004.
- 小西文雄:腹腔鏡下大腸手術の現況と問題点. 大腸疾患NOW. 71-79, 2004.
- 河村裕、小西文雄:腹腔鏡下大腸癌手術-腹腔鏡補助下結腸切除術. 外科治療-癌の標準手術アトラス-. 90: 144-150, 2004.
- 長谷川博俊、渡邊昌彦、西堀英樹、他:腹腔鏡補助下結腸切除術. 手術. 58:59-64, 2004.
- 榎本雅之、杉原健一:大腸癌-進行がんに対する腹腔鏡下手術. 日外会誌. 105(9):494-497, 2004.
- 委員会承認の治療研究
- 主な学会発表
- 委員会承認の治療研究
- JCOG0205
- 島田安博、濱口哲弥、森谷冝皓、他:JCOG0205 Stage III治癒切除大腸がんに対する術後補助療法のランダム化第Ⅲ相比較臨床試験:5FU/l-LV対UFT/LV.第60回日本大腸肛門病学会総会.2005年10月.
- 濱口哲弥、島田安博、斎藤典男、他:JCOG0205 Stage III治癒切除大腸がんに対する術後補助療法のランダム化第III相比較臨床試験)UFT/LVの補助療法としての臨床評価.第44回日本癌治療学会総会.2006年10月.
- グループ代表者管理の治療研究
なし
- 附随研究等
- Y Moriya: Treatment of T4-tumours: extended resection, European Association of Coloproctology. Sep 2002.
- Y Moriya: TPES for fixed recurrent tumor, International Symposium-Sphincter Saving Surgery for rectal cancer. Nov 2002.
- 総説・解説
北野正剛:厚労省班研究からみた腹腔鏡下手術の現況と展望. 第105回日本外科学会定期学術集会. 2005年5月.
- 委員会承認の治療研究






