• サイトマップ
• 求人情報
• アクセス
• お問い合わせ

更新日：2010年8月31日

1. 論文
   1. 委員会承認の治療研究
      • S Shibui, A Asai, T Fujimaki, et al. : Randomized Controlled Trial on Malignant Brain Tumors Activities of The Japan Clinical Oncology Group (JCOG)- Brain Tumor Study Group (BTSG) . Neurol med chirur. 44, 220-221, 2004.
      • S Shibui, Members of JCOG Brain Tumor Study Group: The result of a clinical trial for malignant gliomas by JCOG Brain Tumor Study Group. Neuro-Oncology. 11:892, 2009
   2. グループ代表者管理の治療研究

      なし

   3. 附随研究等
      • M Ohki, K Sakurada, Y Sonoda, et al. : Analysis of the extent of astrocytic tumour resection evaluated by magnetic resonance images. Neurosurg Rev. 26(4):262-5, 2003.
      • B Hu, P Guo, Q Fang, et al. : Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2. Proc Natl Acad Sci. 100(15): 8904-8909, 2003.
      • Y Muragaki, K Suzukawa, H Iseki, T Maruyama, K Nambu, H Aramata, M Sugiura , K Naemura, T Hori, K Takakura: Development of three-dimensional navigation system updated with intraoperative MRI. Computer Assisted Radiology and Surgery. 1360, 2003.
      • A Mukasa, K Ueki, A Asai, et al.: Selective expression of a subset of neuronal genes in oligodendroglioma with chromosome 1p loss. Brain Pathol. 14: 34-42, 2004.
      • M Fujimura, T Kumabe, H Tominaga, et al.: Routine clinical adoption of magnetic resonance imaging was associated with better outcome after surgery in elderly patients with a malignant astrocytic tumour : a retrospective review. Acta Neurochir(Wien). 146: 251-255, 2004.
      • T　Kumabe, N Nakasato, K Nagamatsu, et al.: Intraoperative localization of the lip sensory area by somatosensory evoked potentials-technical note-. J Clin Neurosciece. 12(1): 66-70, 2004.
      • K Kamada, Y Sawamura, F Takeuchi, et al.: Gradual recovery from dyslexia and related serial magnetoencephalographic changes in the lexico-semantic centers after resection of a mesial temporal astrocytoma. J Neurosurg. 100: 1101-1106, 2004.
      • Y Yoshida, K Tanaka, T Hashimoto: The significance of lipid resonances in proton MR spectroscopy of brain tumors. 聖マリアンナ医科大学雑誌. 32(4): 329-338, 2004.
      • A Mukasa , K Ueki, R Nishikawa, et al.: Selective Expression of a Subset of Neuronal Genes in Oligodendroglioma with chromosome 1p loss. Brain Pathology. 14: 34-42, 2004.
      • R Nishikawa, T Sugiyama, Y Narita, et al.: Immunohistochemical analysis of the mutant epidermal growth factor ΔEGFR, in glioblastoma. Brain Tumor Pathology. 21: 53-56, 2004.
      • N Hata, Y Muragaki, T Inomata, et al.: Intraoperative tumor segmentation and volume measurement in MRI-guided glioma surgery for tumor resection rate control. Acad Radiol. 12: 116-122, 2004.
      • Y Muragaki, H Iseki, T Maruyama, et al.: Advanced information-guided surgery by integration of data from different modality. Computer Assisted Radiology and Surgery 2004: International Congress Series. 1268: 693-696, 2004.
      • T Kumabe, N Nakasato, K Nagamatsu, et al.: Intraoperative localization of the lip sensory area by somatosensory evoked potentials-technical note-. J Clin Neurosci. 12 : 66-70, 2005.
      • S Yano, K Makino, H Nakamura, et al.: Comparative clinical study of the anti-emetic effects of oral ramosetron and injected granisetron in patients with malignant glioma undergoing ACNU chemotherapy. Neurol Med Chir. 45 : 294-298, 2005.
      • K Kamada, Y Sawamura, F Takeuchi, et al.: Functional identification of the primary motor area by corticospinal tractography. Neurosurg. 556 : 98-109, 2005.
      • M Tanaka, Y Ino, K Nakagawa, et al.: High-dose conformal radiotherapy for supratentorial malignant glioma: a historical comparison. Lancet Oncology. 6 :953-960, 2005.
      • T Fujimaki : Surgical Treatment of brain metastasis. Int J Clini Oncol. 10 : 74-80, 2005.
      • K Yonemori. M Sumi : Progastrin- releasing peptide as a factor predicting the incidence of brain metastasis in patients with small cell lung carcinoma with limited disease receiving prophylactic cranial irradiation. Cancer. 104 : 811-816, 2005.
      • Y Narita, S Shibui: Cases with carcinomatous meningitis and cerebral infarction. Jpn J Clin Oncol. 36:676, 2006.
      • K Sakurada, S Sato, Y Sonoda, et al: Surgical resection of the tumors located in subcortex of language area. Acta Neurochir (Wien). 149:123-130, 2006.
      • S Higano, X Yun, T Kumabe, et al: Malignant astrocytic tumors: clinical importance of apparent diffusion coefficient in prediction of grade and prognosis. Radiology. 241: 839-846, 2006.
      • Y Muragaki, H Iseki, T Maruyama, et al: Usefulness of intraoperative magnetic resonance imaging for glioma surgery. Acta Neurochir. Suppl 98: 67-75, 2006.
      • T Beppu, K Ogasawara, A Ogawa: Alleviation of intracranial air using carbon dioxide gas during intraventricular tumor resection. Clin Neurol Neurosurg. 108: 665-660,2006.
      • T Serizawa, Y Higuchi, J Ono, et al: Gammma knife radiosurgery for metastatic brain tumors without prophylactic whole-brain radiotherapy: result in 1000 consecutive cases. J Neurosurg. 105: 86-90, 2006.
      • H Aoyama, H Shirato, M Tago, et al: Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. JAMA. 295:2483-2491, 2006.
      • T Kumabe, S Higano, S Takahashi, et al: Ischemic complications associated with resection of opercular glioma. J Neurosurg. 106: 263-269, 2007.
      • K Sakurada, S Sato, Y Sonoda, et al. :Surgical resection of the tumors located in subcortex of language area. Acta Neurochir (Wien). 149:123-130,2007.
      • 渡辺茂樹，櫻田香, 毛利渉:補足運動野症候群を呈した神経膠腫手術例の検討. Brain Nerve. 59:793-796, 2007.
      • K Makino, H Nakamura, M Kudo, et al.:Complete response to temozolomide treatment in an elderly patient with recurrent primary central nervous system lymphoma. Neurol Med Chir. 47:229-232, 2007.
      • T Fujimaki, H Ishii, A Matsuno, et al.: Effectiveness of interferon-beta and temozolomide combination therapy against temozolomide- refractory recurrent anaplastic astrocytoma. World J Surg Oncol. 5:89, 2007.

      その他

      H Aoyama, H Shirato, R Onimura, et al. : Hypofractionated stereotactic radiotherapy alone without whole-brain irradiation for patients with solitary and oligo brain metastasis using noninvasive fixation of the Skull. Int Radiation Oncology Biol Phys. 56: 793-800, 2003.

      H Endo, T Kumabe, H Jokura, et al. : Stereotactic radiosurgery for nodular dissemination of anaplastic ependymoma. Acta Neurochir (Wien). 146: 291-298, 2004.

      Y Shibamoto, E Tsuchida, M Sumi, et al.: Primary central nervous system lymphoma in Japan 1995-1999 : changes from the preceding 10 years. J Cancer Res Clin Oncol. 130(6): 351-356, 2004.

      T Todo, Samuel D. Rabkin: Development of oncolytic replication-competent Herpes simplex virus vectors:The G207 paradigm. Humana Press. 199-210, 2004.

      T Fujimaki: Cell biology of brain tumor : with special emphasis on tumor cell invasion. Neurosurgery Update 2004, Update in Spine surgery and Neuro-Oncology Jung H-W (ed). JMC. 157-160, 2004.

      H Hirano, H Takeshima, M Niiro, et al: The environment of increased concentration of docosa- hexaenoic acid in glioblastoma may suppress the anti-tumor effect of macrophages. Oncol Rep. 13 : 1185-1191, 2005.

      H Takahashi : Stereotactic technique for radiofrequency antenna implantation for brain tumor treatment - Technical note and report of complications -. Jpn J Hyperthermic Oncol. 21: 221-229,2005.

      P Guo, Y Imanishi, FC Cackowski, et al: Up-regulation of angiopoietin- 2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5γ2 correlates with the invasiveness of human glioma. Am J Path. 166 : 877-890, .2005.

      R Kanai, H Tomita, A Shinoda, et al: Enhanced therapeutic efficacy of G207 for the treatment of glioma through Musashi1 promoter retargeting of γ34.5-mediated virulence. Gene Ther. 13 : 106-116, 2005.

      Y Ino, Y Saeki, H Fukunaga, et al: Triple combination of oncolytic Herpes Simplex virus-1 vectors armed with interleukin-12, interleukin-18, or soluble B7-1 results in enhanced antitumor efficacy. Clin Cancer Res. 12: 643-652, 2006.

      K Kamada, F Takeuchi F, S Kuriki, et al: Dissocitated expressive and receptive language functions on magnetoencephalography,functional magnetic resonance image,and amobarbital studies. J Neurosurg. 104: 598-607, 2006.

      S Sugiyama, Y Yamashita, T Kikuchi, et al: Safey and efficacy of convection-enhanced delivery of ACNU, a hydrophilic nitrosourea, in intracranial brain tumor model. J Neurooncol. 82: 41-47, 2007.

      K Kamada, Y Sawamura, F Takeuchi, et al :Expressive and receptive language areas determined by a non-invasive reliable method co-using functional magnetic resonance imaging and magnetoencephalography. Neurosurgery. 60:296-306, .2007.

      M Nagane, WK Cavenee, Y Shiokawa　:Synergistic cytotoxicity through the activation of multiple apoptosis pathways in human glioma cells induced by combined treatment with ionizing radiation and tumor necrosis factor-related apoptosis-inducing ligand. J Neurosurg. 106:407-416, .2007.

      T Aoki, R Nishikawa T, Mizutani, et al.:Pharmacokinetic study of temozolomide on a daily-for-5-days schedule in Japanese patients with relapsed malignant gliomas: first study in Asians. Int J Oncol. 12:341-349, .2007.

      B Hu, P Guo, I Bar-Joseph, et al.:Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway. Oncogene. 26:5577-5586, .2007.

      MJ Jarzynka, B Hu, KM Hui, et al.:ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion. Cancer Res. 67:7203-7211, .2007.

      T Beppu, T Inoue, H Nishimoto, et al.:Preoperative imaging of superficially located glioma resection using short inversion-time inversion recovery images in high-field magnetic resonance imaging. Clin Neurol Neurosurg. 109:327-334, .2007.

      H Kashimura, T Inoue, T Beppu, et al.:Diffusion tensor imaging for differentiation of recurrent brain tumor and radiation necrosis after radiotherapy-Three case reports. Clin Neurol Neurosurg. 109:106-110, 2007.

   4. 総説・解説
      • 嘉山孝正：転移性脳腫瘍の治療戦略．吉田純．斎藤清編．脳神経外科の治療戦略と成績 - 前方視的調査2003-2004. 医学書院. 2005
      • 佐藤慎哉、嘉山孝正：転移性脳腫瘍に対する臨床試験．脳神経外科速報.15：937-942, 2005.
      • 渋井壮一郎：悪性脳腫瘍治療の新しい展開　化学療法の新展開．Jpn J Cancer Chemother. 32 : 441-447, 2005.
      • 渋井壮一郎、宮北康二、大西晶子、他: 星細胞腫grade3/4に対するACNU vs ACNU+PCZによる第II/III相試験（JCOG0305臨床試験）. Neuro-Oncology. 15:50-53, 2005.
      • 渋井壮一郎：悪性グリオーマに対する化学療法ー大規模臨床試験とテーラーメイド治療ー. Jpn J Neurosurg. 15 : 3-9, 2006.
      • 渋井壮一郎：脳腫瘍に対する新しい治療． 医学のあゆみ. 222:953-954, 2007.
      • 成田善孝，渋井壮一郎：新しい神経疾患の動き．グリオーマ．脳神経外科ジャーナル. 25:1242-1246, 2007.
      • 永根基雄:悪性神経膠腫の化学療法. No Shinkei Geka 35:433-450,2007.
      • Y Narita, S Shibui: Strategy of surgery and radiation therapy for brainmetastases. Int J Clin Oncol. 14:275-280,2009.
      • S Shibui :Treatment of metastatic brain tumors. Int J Clin Oncol. 14:273-274, 2009.
2. 主な学会発表
   1. 委員会承認の治療研究
      • 渋井壮一郎：転移性脳腫瘍の病理と治療．第24回日本脳腫瘍病理学会．2006年6月.
      • S Shibui, T Kayama: A clinical trial for metastatic brain tumors in Japan (JCOG 0504). 17th Joint Congress of Asia & Pacific Federations & 53rd Annual Congress of the Japan Section. Jun 2006.
      • 渋井壮一郎、嘉山孝正：シンポジウム　悪性グリオーマの定位放射線治療．悪性グリオーマに対する多施設共同試験　－JCOG脳腫瘍グループの活動－　第15回日本定位放射線治療学会．2006年7月.
      • 渋井壮一郎：シンポジウム19　悪性脳腫瘍に対する新規治療の展望．悪性脳腫瘍に対する化学療法の展望．第44回日本癌治療学会総会.2006年10月.
      • 渋井壮一郎：JCOG脳腫瘍グループによる多施設共同臨床試験．第24回日本脳腫瘍学会．2006年10月.
      • 嘉山孝正：転移性脳腫瘍に対するSRS・SRTの展望-世界標準の転移性脳腫瘍治療プロトコール．第44回日本癌治療学会総会．2006年10月.
      • 渋井壮一郎：星細胞腫grade 3・4に対するランダム化第II/III相試験(JCOG 0305)結果．第25回日本脳腫瘍学会．2007年12月．
      • S Shibui: A ranodmized controlled study for malignant gliomas by JCOG-Brain Tumor Study Group. 5th Meeting of The Asian Society for Neuro-oncology. Nov 2007.
      • S Shibui: Clinical trials for malignant gliomas in Japan. 2007 Samsung International Brain Tumor Symposium. Sep 2007.
      • S Shibui: A clinical trial for metastatic brain tumors in Japan (JCOG 0504). 17th Joint Congress of Asia & Pacific Federations & 53rd Annual Congress of the Japan Section. Jun 2007.
   2. グループ代表者管理の治療研究
      • 渋井壮一郎：悪性脳腫瘍治療におけるEBM Japan Clinical Oncology Group（JCOG）脳腫瘍研究グループの活動. 第62回日本脳神経外科学会総会. シンポジウム-8. 日本発の脳神経外科領域EBM. 2003年10月.
      • 渋井壮一郎：放射線治療. 第63回日本癌学会総会. シンポジウム. 悪性脳腫瘍に対する新しい治療戦略. 2004年9月.
      • 渋井壮一郎、JCOG脳腫瘍研究グループ：悪性脳腫瘍に対する多施設共同試験：JCOG脳腫瘍研究グループの活動. 第63回日本脳神経外科学会総会. シンポジウム「脳外科領域の大規模試験の現状と将来」. 2004年10月.
      • 渋井壮一郎、淺井昭雄、嘉山孝正、他：星細胞腫Grade34に対するACNU単独療法とProcarbazine+ ACNU併用療法とのランダム化第II/III相多施設共同試験. 第22回日本脳腫瘍学会. 2004年10月.
      • S Shibui: Randomized controlled trial on malignant gliomas by Japan Clinical Oncology Group-Brain Tumor Study Group (JCOG-BTSG). 3rd Meeting of the Asian Society for Neuro-Oncology. Nov 2004.
      • 渋井壮一郎：悪性脳腫瘍：標準化治療と治療抵抗性への挑戦．化学療法（標準治療とテーラーメイド化学療法の最新知見）.第25回日本脳神経外科コングレス．2005年5月.
      • 嘉山孝正：標準医療の意義と解釈　ー外科の立場から．第25回日本脳神経外科コングレス．2005年5月.
      • S Shibui, The members of JCOG-Brain Tumor Study Group: Randomized controlled trial on malignant gliomas by JCOG-Brain Tumor Study Group (JCOG-BTSG). The 15th Annual Meeting of Korean Brain Tumor Society. Jul 2005.
      • 渋井壮一郎：グリオーマに対する化学療法のevidence: JCOG studyを踏まえて. 第64回社団法人日本脳神経外科学会総会．2005年10月.
      • 嘉山孝正：転移性脳腫瘍治療のスタンダード：JCOG studyを踏まえて-共同研究報告-．第64回日本脳神経外科学会総会．2005年10月.
      • 渋井壮一郎、JCOG脳腫瘍研究グループ : 悪性神経膠腫に対するJCOG脳腫瘍研究グループによる多施設共同試験. 第23回日本脳腫瘍学会．2005年10月.
      • S Shibui, JCOG Brain Tumor Study group：The 4th Meeting of the Asian Society for Neuro-Oncology. Nov 2005.
      • 渋井壮一郎、宮北康二、大西晶子、他：星細胞腫grade3/4に対するACNU vs ACNU+PCZによる第II/III相試験（JCOG0305臨床試験）. 第30回ニューロオンコロジイの会．2005年12月.
      • S Shibui, The members of JCOG-BTSG : Randomized controlled trial on malignant gliomas by JCOG-Brain Tumor Study. 2006 International Brain Tumor Research and Therapy Meeting. Apr 2006.
      • 渋井壮一郎：悪性グリオーマ治療のスタンダード．第27回日本脳神経外科コングレス総会．2007年5月．
      • 渋井壮一郎：悪性グリオーマに対する化学療法．第25回日本脳腫瘍病理学会．2007年4月．
      • 渋井壮一郎：シンポジウム19　悪性脳腫瘍に対する新規治療の展望．悪性脳腫瘍に対する化学療法の展望．第44回日本癌治療学会総会．2006年10月．
      • T Wakabayashi, A Natsume, M Fujii, et al: Interim report of combination therapy with interferon-beta and temozolomide for malignant glioma (Integra study). XIV world congress of neurological surgery. Boston,August　2009.
      • T Wakabayashi :Present and future of management of glioma. 58th annual conference of neurological society of India.Lucknow.Inida, December　2009.
   3. 附随研究等

      なし

   4. 総説・解説

      なし